T-1840383 is an inhibitor of VEGF-induced VEGFR-2 phosphorylation and HGF-induced c-Met phosphorylation in vascular endothelial cells and cancer epithelial cells.
FmocNH-PEG4-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Hydroxy-PEG12-t-butyl ester is a PEG derivative containing a hydroxyl group and a t-butyl ester. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. Under acidic conditions, the t-butyl protected carbox
T-1095A is an active metabolite of T-1095, a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). Chronic administration of T-1095 (0.1% w w(-1) pellet chow, for 12 weeks) decreased blood glucose and haemoglobin A(1C) levels, and improved
t-Butyl acetate-PEG3-CH2COOH is a polyethylene glycol-derived PROteolysis TArgeting Chimera (PROTAC) linker, specifically designed for incorporation into the synthesis of PROTAC molecules.
SV40 large T antigen NLS, originating from Large T antigen residue 47 to 55, facilitates protein import into the cell nucleus. This peptide is specifically generated from Large T antigen residue 47 to 55.
Peptide T (TFA) is an octapeptide derived from the V2 region of HIV-1 gp120. It serves as a ligand for the CD4 receptor, effectively inhibiting the binding of HIV to the CD4 receptor.
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. This synthetic octapeptide potentially functions through competitive inhibition of gp120 binding to the CD4 receptor, as well as interaction with vasointestinal peptide (VIP) receptors.
t-Boc-Aminooxy-PEG7-methane is a polyethylene glycol (PEG)-based linker, which finds application in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition. This compound plays a crucial role in the synthesis of a range of PROTACs, including BI-3663, a highly selective PTK2 FAK PROTAC. It employs cereblon ligands to target E3 ligases for the degradation of PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].
t-Boc-Aminooxy-PEG5-azide is a polyethylene glycol (PEG) derivative that serves as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
N-(Propargyl-PEG2)-N-Boc-PEG3-t-butyl ester is a polyethylene glycol (PEG)-based linker employed for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].